CCNE1 Recombinant Monoclonal Antibody

Uniprot Id

P24864

Target Species

Human

Target Name

CCNE1

Target Full Name

G1/S-specific cyclin-E1

Target Function

Essential for the control of the cell cycle at the G1/S (start) transition.

Target Subcellular Location

Nucleus.

Target Protein Families

Cyclin family, Cyclin E subfamily

Target Tissue Specificity

Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

Target Synonyms

CCNE; Ccne1; CCNE1_HUMAN; cyclin E variant ex5del; cyclin E variant ex7del; Cyclin E1; Cyclin Es; Cyclin Et; CyclinE; G1/S specific cyclin E; G1/S-specific cyclin-E1

Target Background

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.