Rabbit anti-Human SYT4 Polyclonal Antibody

The antibody against SYT4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 38-190 of human SYT4 (NP_065834.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-00068A

Number

Cat.No	ADA-00068A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SYT4
Target Synonyms	HsT1192; SYT4	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	A-431, Mouse brain	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-00068A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SYT4

Target Synonyms

HsT1192; SYT4

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

A-431, Mouse brain

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 38-190 of human SYT4 (NP_065834.1).	Target Species	Human
Immunogen Sequence	CQRKSSKSNKTPPYKFVHVLKGVDIYPENLNSKKKFGADDKNEVKNKPAVPKNSLHLDLEKRDLNGNFPKTNLKPGSPSDLENATPKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTS	Uniprot ID	Q9H2B2

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 38-190 of human SYT4 (NP_065834.1).

Target Species

Human

Immunogen Sequence

CQRKSSKSNKTPPYKFVHVLKGVDIYPENLNSKKKFGADDKNEVKNKPAVPKNSLHLDLEKRDLNGNFPKTNLKPGSPSDLENATPKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTS

Uniprot ID

Q9H2B2

Background Information

Uniprot Id

Q9H2B2
Target Species

Human
Target Name

SYT4
Target Full Name

Synaptotagmin-4
Target Function

Synaptotagmin family member which does not bind Ca(2+). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses. Plays a role in dendrite formation by melanocytes.
Target Subcellular Location

Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Single-pass membrane protein.
Target Protein Families

Synaptotagmin family
Target Tissue Specificity

Expressed in melanocytes. Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus.
Target Synonyms

SYT4; KIAA1342; Synaptotagmin-4; Synaptotagmin IV; SytIV
Target Background

Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in negative regulation of catecholamine secretion and positive regulation of dendrite extension. Predicted to be located in several cellular components, including microvesicle; perinuclear region of cytoplasm; and secretory vesicle. Predicted to be active in several cellular components, including axon; exocytic vesicle; and glutamatergic synapse. Predicted to be integral component of neuronal dense core vesicle membrane.

Rabbit anti-Human SYT4 Polyclonal Antibody

Specifications

Immunogen Information

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