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The antibody against USP21 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human USP21 (NP_036607.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against USP21 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human USP21 (NP_036607.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-00146A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | USP21 |
| Target Synonyms | USP16; USP23; USP21 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain | Application | ELISA, WB, IF/ICC |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human USP21 (NP_036607.3). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MPQASEHRLGRTREPPVN | Uniprot ID | Q9UK80 |
Uniprot Id
Q9UK80
Target Species
Human
Target Name
USP21
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 21
Target Function
Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Peptidase C19 family, USP21 subfamily
Target Tissue Specificity
Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
Target Research Area
Cell Biology
Target Synonyms
Deubiquitinating enzyme 21; deubiquitinating enzyme 23; EC 3.1.2.15; ESTM28; MGC3394; NEDD8-specific protease; Ubiquitin carboxyl terminal hydrolase 21; ubiquitin carboxyl terminal hydrolase 23; Ubiquitin carboxyl-terminal hydrolase 21; ubiquitin specific peptidase 21; Ubiquitin specific processing protease 21; ubiquitin specific protease 16; ubiquitin specific protease 21; ubiquitin specific protease 23; Ubiquitin thioesterase 21; Ubiquitin thiolesterase 21; ubiquitin thiolesterase 23; ubiquitin-specific protease 23, formerly; Ubiquitin-specific-processing protease 21; UBP21_HUMAN; USP16; Usp21; USP23; USP23, formerly; W53272
Target Background
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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