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The antibody against COMMD5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human COMMD5 (NP_054785.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against COMMD5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human COMMD5 (NP_054785.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-00239A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | COMMD5 |
| Target Synonyms | HCARG; HT002; COMMD5 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293F, MCF7, PC-3 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human COMMD5 (NP_054785.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9GZQ3 | Immunogen Sequence |
Uniprot Id
Q9GZQ3
Target Species
Human
Target Name
COMMD5
Target Full Name
COMM domain-containing protein 5
Target Function
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Tissue Specificity
Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.
Target Research Area
Transcription
Target Synonyms
COMMD5; HT002COMM domain-containing protein 5; Hypertension-related calcium-regulated gene protein; HCaRG
Target Background
Predicted to be involved in proximal tubule morphogenesis. Located in cytosol and nucleoplasm.
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