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The antibody against HEBP2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human HEBP2 (NP_055135.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against HEBP2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human HEBP2 (NP_055135.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-00248A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HEBP2 |
| Target Synonyms | PP23; SOUL; C6orf34; C6ORF34B; HEBP2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | COS-7, Mouse lung | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human HEBP2 (NP_055135.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y5Z4 | Immunogen Sequence |
Uniprot Id
Q9Y5Z4
Target Species
Human
Target Name
HEBP2
Target Full Name
Heme-binding protein 2
Target Function
Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.
Target Subcellular Location
Cytoplasm. Mitochondrion.
Target Protein Families
HEBP family
Target Tissue Specificity
Detected in placenta.
Target Research Area
Cell Biology
Target Synonyms
C6orf34; Chromosome 6 open reading frame 34; Hebp2; HEBP2_HUMAN; Heme binding protein 2; Heme-binding protein 2; Placental protein 23; PP23; Protein SOUL; SOUL
Target Background
The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress.
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