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The antibody against PRG3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 18-225 of human PRG3 (NP_006084.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PRG3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 18-225 of human PRG3 (NP_006084.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00266A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PRG3 |
| Target Synonyms | MBP2; MBPH; PRG3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse spleen, Mouse thymus, Rat thymus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 18-225 of human PRG3 (NP_006084.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y2Y8 | Immunogen Sequence |
Uniprot Id
Q9Y2Y8
Target Species
Human
Target Name
PRG3
Target Full Name
Proteoglycan 3
Target Function
Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.
Target Subcellular Location
Cytoplasmic granule. Note=Localized to the eosinophil secondary granule.
Target Tissue Specificity
Expressed in bone marrow. Not detected in placenta.
Target Synonyms
PRG3; MBPH; UNQ486/PRO1002Proteoglycan 3; Eosinophil major basic protein homolog; Prepro-major basic protein homolog; Prepro-MBPH
Target Background
An extracellular matrix structural constituent conferring compression resistance. Involved in several processes, including granulocyte activation; histamine biosynthetic process; and regulation of gene expression. Located in collagen-containing extracellular matrix.
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