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The antibody against BMP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 725-986 of human BMP1 (NP_006120.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against BMP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 725-986 of human BMP1 (NP_006120.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of HeLa cells using BMP1 Rabbit pAb at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
| Cat.No | ADA-00334A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BMP1 |
| Target Synonyms | PCP; TLD; OI13; PCP2; PCOLC; BMP1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 725-986 of human BMP1 (NP_006120.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P13497 | Immunogen Sequence |
Uniprot Id
P13497
Target Species
Human
Target Name
BMP1
Target Full Name
Bone morphogenetic protein 1
Target Function
Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation.; Plays an important role in bone repair by acting as a coactivator of BMP7.
Target Involvement
Osteogenesis imperfecta 13 (OI13)
Target Subcellular Location
Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Secreted.; [Isoform BMP1-3]: Secreted.
Target Protein Families
Peptidase M12A family
Target Tissue Specificity
Ubiquitous.
Target Research Area
Developmental Biology
Target Synonyms
BMP 1; BMP-1; BMP1; BMP1_HUMAN; Bone morphogenetic protein 1; Mammalian tolloid protein; mTld; OI13; PCOLC; PCP; PCP2; Procollagen C endopeptidase; Procollagen C proteinase; Procollagen C-proteinase; TLD; Tolloid; Drosophila; homolog of
Target Background
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.
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