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The antibody against ANO2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ANO2 (NP_001265526.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against ANO2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ANO2 (NP_001265526.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-00471A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ANO2 |
| Target Synonyms | C12orf3; TMEM16B; ANO2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ANO2 (NP_001265526.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLK | Uniprot ID | Q9NQ90 |
Uniprot Id
Q9NQ90
Target Species
Human
Target Name
ANO2
Target Full Name
Anoctamin-2
Target Function
Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
Anoctamin family
Target Tissue Specificity
Retina, especially in the photoreceptor synaptic terminals.
Target Synonyms
Ano2; ANO2_HUMAN; Anoctamin 2; Anoctamin-2; C12orf3; Chromosome 12 open reading frame 3; DKFZp434P102; Transmembrane protein 16B (eight membrane-spanning domains); Transmembrane protein 16B
Target Background
ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).
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