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The antibody against RGN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human RGN (NP_004674.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against RGN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human RGN (NP_004674.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00478A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RGN |
| Target Synonyms | RC; GNL; SMP30; HEL-S-41; RGN | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, Rat kidney, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human RGN (NP_004674.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q15493 | Immunogen Sequence |
Uniprot Id
Q15493
Target Species
Human
Target Name
RGN
Target Full Name
Regucalcin
Target Function
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities.
Target Subcellular Location
Cytoplasm.
Target Protein Families
SMP-30/CGR1 family
Target Synonyms
Gluconolactonase; GNL; RC; Regucalcin; RGN; RGN_HUMAN; Senescence marker protein 30; SMP 30 ; SMP-30
Target Background
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants.
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