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The antibody against FAF1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FAF1 (NP_008982.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against FAF1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FAF1 (NP_008982.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00499A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FAF1 |
| Target Synonyms | hFAF1; CGI-03; HFAF1s; UBXD12; UBXN3A; FAF1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, HT-29, Mouse brain, Mouse liver, OVCAR3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FAF1 (NP_008982.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UNN5 | Immunogen Sequence |
Uniprot Id
Q9UNN5
Target Species
Human
Target Name
FAF1
Target Full Name
FAS-associated factor 1
Target Function
Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.
Target Synonyms
CGI 03; FAF1; FAF1 protein; FAF1_HUMAN; Fas (TNFRSF6) associated factor 1; FAS associated factor 1; Fas associated protein factor 1; FAS-associated factor 1; FLJ37524; hFAF1; HFAF1s; Protein FAF1; TNFRSF6 associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A
Target Background
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.
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