Rabbit anti-Human MCF2L Polyclonal Antibody

The antibody against MCF2L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 850-980 of human MCF2L (NP_079255.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-00840A

Number

Cat.No	ADA-00840A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	MCF2L
Target Synonyms	DBS; OST; ARHGEF14; MCF2L	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse heart, Mouse kidney, MCF7, Mouse lung	Application	ELISA, WB

Cat.No

ADA-00840A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

MCF2L

Target Synonyms

DBS; OST; ARHGEF14; MCF2L

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse heart, Mouse kidney, MCF7, Mouse lung

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 850-980 of human MCF2L (NP_079255.4).	Target Species	Human
Immunogen Sequence	YEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEK	Uniprot ID	O15068

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 850-980 of human MCF2L (NP_079255.4).

Target Species

Human

Immunogen Sequence

YEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEK

Uniprot ID

O15068

Background Information

Uniprot Id

O15068
Target Species

Human
Target Name

MCF2L
Target Full Name

Guanine nucleotide exchange factor DBS
Target Function

Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42.; Does not catalyze guanine nucleotide exchange on CDC42.
Target Subcellular Location

[Isoform 5]: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 3]: Cytoplasm. Endomembrane system.; Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families

MCF2 family
Target Synonyms

ARHGEF 14; DBL''s big sister; DBS; FLJ12122; Guanine nucleotide exchange factor DBS; KIAA0362; MCF 2L; MCF.2 cell line derived transforming sequence like; MCF.2 transforming sequence-like; MCF2 like protein; MCF2 transforming sequence like protein; MCF2-transforming sequence-like protein; Mcf2l; MCF2L_HUMAN; OST; OST oncogene
Target Background

This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants.

Rabbit anti-Human MCF2L Polyclonal Antibody

Specifications

Immunogen Information

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