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The antibody against B3GAT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 35-334 of human B3GAT1 (NP_473366.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against B3GAT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 35-334 of human B3GAT1 (NP_473366.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00887A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | B3GAT1 |
| Target Synonyms | NK1; CD57; HNK1; LEU7; NK-1; GLCATP; GLCUATP; B3GAT1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BT-474, HT-1080, SW480 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 35-334 of human B3GAT1 (NP_473366.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9P2W7 | Immunogen Sequence |
Uniprot Id
Q9P2W7
Target Species
Human
Target Name
B3GAT1
Target Full Name
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
Target Function
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
Target Subcellular Location
[Isoform 1]: Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.; [Isoform 2]: Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Secreted.
Target Protein Families
Glycosyltransferase 43 family
Target Tissue Specificity
Mainly expressed in the brain.
Target Synonyms
3-glucuronyltransferase 1; 3-glucuronyltransferase; B3GA1_HUMAN; B3gat1; Beta 1 3 glucuronyltransferase 1; Beta-1; Beta-1,3-glucuronyltransferase 1; CD 57; CD57; CD57 antigen; Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 1; Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; GlcAT P; GlcAT-P; GLCATP; GlcUAT P; GlcUAT-P; GlcUATP; Glucuronosyltransferase P; HNK 1; HNK1; LEU 7; LEU7; LEU7 antigen; NK 1; NK1; UDP GlcUA glycoprotein beta 1 3 glucuronyltransferase; UDP-GlcUA:glycoprotein beta-1
Target Background
The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized.
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