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The antibody against CLEC16A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 330-550 of human CLEC16A (NP_001230332.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CLEC16A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 330-550 of human CLEC16A (NP_001230332.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00935A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CLEC16A |
| Target Synonyms | Gop-1; KIAA0350; CLEC16A | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, B cells, LO2, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 330-550 of human CLEC16A (NP_001230332.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q2KHT3 | Immunogen Sequence |
Uniprot Id
Q2KHT3
Target Species
Human
Target Name
CLEC16A
Target Full Name
Protein CLEC16A
Target Function
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
Target Involvement
Diabetes mellitus, insulin-dependent (IDDM)
Target Subcellular Location
Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
Target Protein Families
CLEC16A/gop-1 family
Target Tissue Specificity
Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells.
Target Synonyms
CLEC16A; KIAA0350Protein CLEC16A; C-type lectin domain family 16 member A
Target Background
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene.
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