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The antibody against MTO1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 420-680 of human MTO1 (NP_036255.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MTO1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 420-680 of human MTO1 (NP_036255.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01043A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MTO1 |
| Target Synonyms | CGI-02; COXPD10; MTO1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Mouse kidney, MCF7, Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 420-680 of human MTO1 (NP_036255.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y2Z2 | Immunogen Sequence |
Uniprot Id
Q9Y2Z2
Target Species
Human
Target Name
MTO1
Target Full Name
Protein MTO1 homolog, mitochondrial
Target Function
Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
Target Involvement
Combined oxidative phosphorylation deficiency 10 (COXPD10)
Target Subcellular Location
Mitochondrion.
Target Protein Families
MnmG family
Target Tissue Specificity
Ubiquitously expressed in various tissues, but with a markedly elevated expression in tissues of high metabolic rates including cochlea.
Target Synonyms
CGI-02; COXPD10; MTO1
Target Background
This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene.
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