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The antibody against HERC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human HERC3 (NP_055421.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HERC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human HERC3 (NP_055421.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01169A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HERC3 |
| Target Synonyms | HERC3 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-431, Mouse lung, Mouse spinal cord, SH-SY5Y, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human HERC3 (NP_055421.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGA | Uniprot ID | Q15034 |
Uniprot Id
Q15034
Target Species
Human
Target Name
HERC3
Target Full Name
Probable E3 ubiquitin-protein ligase HERC3
Target Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Target Subcellular Location
Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures.
Target Synonyms
HERC3; KIAA0032Probable E3 ubiquitin-protein ligase HERC3; EC 2.3.2.26; HECT domain and RCC1-like domain-containing protein 3; HECT-type E3 ubiquitin transferase HERC3
Target Background
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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