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Rabbit anti-Human TBXA2R Polyclonal Antibody

The antibody against TBXA2R was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 229-343 of human TBXA2R (NP_001051.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01310A

The antibody against TBXA2R was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 229-343 of human TBXA2R (NP_001051.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-01310A ClonalityPolyclonal
Host SpeciesRabbitTarget NameTBXA2R
Target SynonymsTXA2-R; BDPLT13; TBXA2RFormLiquid
Species ReactivityHuman, MouseIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive SamplesHeLa, A-549, HepG2, K-562, Mouse lungApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 229-343 of human TBXA2R (NP_001051.1).Target SpeciesHuman
Immunogen SequenceQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQUniprot IDP21731
Background Information
  • Uniprot Id

    P21731

  • Target Species

    Human

  • Target Name

    TBXA2R

  • Target Full Name

    Thromboxane A2 receptor

  • Target Function

    Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.; Activates adenylyl cyclase.; Inhibits adenylyl cyclase.

  • Target Involvement

    Bleeding disorder, platelet-type 13 (BDPLT13)

  • Target Subcellular Location

    Cell membrane; Multi-pass membrane protein.

  • Target Protein Families

    G-protein coupled receptor 1 family

  • Target Synonyms

    TBXA2R; Thromboxane A2 receptor; TXA2-R; Prostanoid TP receptor

  • Target Background

    This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene.

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