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The antibody against IGFALS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 396-605 of human IGFALS (NP_004961.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against IGFALS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 396-605 of human IGFALS (NP_004961.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01343A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IGFALS |
| Target Synonyms | ALS; ACLSD; IGFALS | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse lung, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 396-605 of human IGFALS (NP_004961.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P35858 | Immunogen Sequence |
Uniprot Id
P35858
Target Species
Human
Target Name
IGFALS
Target Full Name
Insulin-like growth factor-binding protein complex acid labile subunit
Target Function
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
Target Involvement
Acid-labile subunit deficiency (ACLSD)
Target Subcellular Location
Secreted, extracellular space.
Target Tissue Specificity
Plasma.
Target Synonyms
IGFALS; ALSInsulin-like growth factor-binding protein complex acid labile subunit; ALS
Target Background
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.
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