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The antibody against HPSE2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 42-242 of human HPSE2 (NP_068600.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against HPSE2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 42-242 of human HPSE2 (NP_068600.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-01571A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HPSE2 |
| Target Synonyms | UFS; HPA2; HPR2; UFS1; HPSE2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, 22Rv1, BT-474, Mouse brain, Mouse small intestine, Mouse testis, Mouse uterus, SKOV3 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 42-242 of human HPSE2 (NP_068600.4). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8WWQ2 | Immunogen Sequence |
Uniprot Id
Q8WWQ2
Target Species
Human
Target Name
HPSE2
Target Full Name
Inactive heparanase-2
Target Function
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
Target Involvement
Urofacial syndrome 1 (UFS1)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
Glycosyl hydrolase 79 family
Target Tissue Specificity
Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and
Target Synonyms
HPSE2; HPA2; Inactive heparanase-2; Hpa2
Target Background
This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants.
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