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The antibody against TBX4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 296-545 of human TBX4 (NP_060958.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TBX4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 296-545 of human TBX4 (NP_060958.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01672A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TBX4 |
| Target Synonyms | SPS; ICPPS; PAPPAS; TBX4 | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 296-545 of human TBX4 (NP_060958.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P57082 | Immunogen Sequence |
Uniprot Id
P57082
Target Species
Human
Target Name
TBX4
Target Full Name
T-box transcription factor TBX4
Target Function
Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs.
Target Involvement
Ischiocoxopodopatellar syndrome (ICPPS)
Target Subcellular Location
Nucleus.
Target Synonyms
SPS; T box 4 ; T box protein 4; T box transcription factor TBX 4; T box transcription factor TBX4; T-box protein 4; T-box transcription factor TBX4; TBX 4; TBX4; TBX4_HUMAN
Target Background
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity.
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