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The antibody against STK36 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 250-450 of human STK36 (NP_056505.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against STK36 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 250-450 of human STK36 (NP_056505.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01727A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | STK36 |
| Target Synonyms | FU; CILD46; STK36 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain, Mouse testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 250-450 of human STK36 (NP_056505.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NRP7 | Immunogen Sequence |
Uniprot Id
Q9NRP7
Target Species
Human
Target Name
STK36
Target Full Name
Serine/threonine-protein kinase 36
Target Function
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family
Target Tissue Specificity
Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.
Target Synonyms
FU; Fused homolog; KIAA1278; Serine/threonine kinase 36, fused homolog; Serine/threonine protein kinase 36 fused homolog; Serine/threonine-protein kinase 36; STK36; STK36_HUMAN
Target Background
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants.
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