Rabbit anti-Human ARHGEF11 Polyclonal Antibody

The antibody against ARHGEF11 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human ARHGEF11 (O15085) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-01855A

Number

Cat.No	ADA-01855A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ARHGEF11
Target Synonyms	GTRAP48; PDZ-RHOGEF; ARHGEF11	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse lung	Application	ELISA, WB, IHC-P

Cat.No

ADA-01855A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ARHGEF11

Target Synonyms

GTRAP48; PDZ-RHOGEF; ARHGEF11

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse lung

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ARHGEF11 (O15085).	Target Species	Human
Immunogen Sequence	MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNS	Uniprot ID	O15085

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ARHGEF11 (O15085).

Target Species

Human

Immunogen Sequence

MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNS

Uniprot ID

O15085

Background Information

Uniprot Id

O15085
Target Species

Human
Target Name

ARHGEF11
Target Full Name

Rho guanine nucleotide exchange factor 11
Target Function

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
Target Subcellular Location

Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation.
Target Tissue Specificity

Ubiquitously expressed.
Target Synonyms

ARHGB_HUMAN; ARHGEF 11; ARHGEF11; DKFZp667F1223; Glutamate transporter EAAT4 associated protein 48; GTRAP 48; GTRAP48; KIAA0380; OTTHUMP00000038716; OTTHUMP00000038717; PDZ RHOGEF; PDZ-RhoGEF; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; Rho guanine nucleotide exchange factor 11; RhoA specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator
Target Background

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

Rabbit anti-Human ARHGEF11 Polyclonal Antibody

Specifications

Immunogen Information

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