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The antibody against CALU was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-315 of human CALU (NP_001210.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against CALU was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-315 of human CALU (NP_001210.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of HeLa cells using CALU antibody. Blue: DAPI for nuclear staining.
| Cat.No | ADA-02354A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CALU |
| Target Synonyms | CALU; calumenin | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 20-315 of human CALU (NP_001210.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O43852 | Immunogen Sequence |
Uniprot Id
O43852
Target Species
Human
Target Name
CALU
Target Full Name
Calumenin
Target Function
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity.
Target Subcellular Location
Endoplasmic reticulum membrane. Golgi apparatus. Secreted. Melanosome. Sarcoplasmic reticulum lumen.
Target Protein Families
CREC family
Target Tissue Specificity
Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.
Target Synonyms
CALU; CALU_HUMAN; Calumenin 1; Calumenin 2; Calumenin; Crocalbin; crocalbin-like protein; FLJ90608; IEF SSP 9302; multiple EF-hand protein; OTTHUMP00000212712; OTTHUMP00000212713; OTTHUMP00000212714; OTTHUMP00000212715
Target Background
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
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