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The antibody against STXBP2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human STXBP2 (NP_001120868.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against STXBP2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human STXBP2 (NP_001120868.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02360A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | STXBP2 |
| Target Synonyms | FHL5; UNC18B; Hunc18b; UNC18-2; pp10122; unc-18B; MUNC18-2; STXBP2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse thymus, Rat fat | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human STXBP2 (NP_001120868.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q15833 | Immunogen Sequence |
Uniprot Id
Q15833
Target Species
Human
Target Name
STXBP2
Target Full Name
Syntaxin-binding protein 2
Target Function
Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
Target Involvement
Familial hemophagocytic lymphohistiocytosis 5 (FHL5)
Target Protein Families
STXBP/unc-18/SEC1 family
Target Tissue Specificity
Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
Target Synonyms
FHL5; Hunc18b; MUNC18 2; pp10122; Protein unc-18 homolog 2; Protein unc-18 homolog B; STXB2_HUMAN; Stxbp2; syntaxin binding protein 2; Syntaxin-binding protein 2; Unc-18B; UNC18 2; Unc18-2; UNC18B
Target Background
This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
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