Rabbit anti-Human NCR3 Polyclonal Antibody

Uniprot Id

O14931

Target Species

Human

Target Name

NCR3

Target Full Name

Natural cytotoxicity triggering receptor 3

Target Function

Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Natural cytotoxicity receptor (NCR) family

Target Tissue Specificity

Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.

Target Synonyms

NCR3; 1C7; LY117; Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; NKp30; CD antigen CD337

Target Background

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.