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The antibody against APIP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human APIP (NP_057041.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against APIP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human APIP (NP_057041.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-02683A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | APIP |
| Target Synonyms | APIP2; CGI29; hAPIP; CGI-29; MMRP19; APIP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, 22Rv1, Mouse liver, Mouse pancreas, Mouse stomach, Rat stomach | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human APIP (NP_057041.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96GX9 | Immunogen Sequence |
Uniprot Id
Q96GX9
Target Species
Human
Target Name
APIP
Target Full Name
Methylthioribulose-1-phosphate dehydratase
Target Function
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Aldolase class II family, MtnB subfamily
Target Tissue Specificity
Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.
Target Research Area
Cell Biology
Target Synonyms
Apaf1 Interacting Protein; APAF1-interacting protein; APIP; APIP2; CG129; CGI 29; CGI29; dJ179L10.2; MMRP19; Monocyte/macrophage protein 19; MTNB_HUMAN; MTRu 1 P dehydratase; MTRu-1-P dehydratase; Probable methylthioribulose 1 phosphate dehydratase; Probable methylthioribulose-1-phosphate dehydratase
Target Background
Enables identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Involved in several processes, including L-methionine salvage from methylthioadenosine; protein homotetramerization; and pyroptosis. Located in cytoplasm.
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