Rabbit anti-Human ADA2 Polyclonal Antibody

Uniprot Id

Q9NZK5

Target Species

Human

Target Name

ADA2

Target Full Name

Adenosine deaminase 2

Target Function

Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.

Target Involvement

Polyarteritis nodosa (PAN); Sneddon syndrome (SNDDS)

Target Subcellular Location

Secreted.

Target Protein Families

Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family, ADGF subfamily

Target Tissue Specificity

Detected in blood plasma (at protein level). Widely expressed, with most abundant expression in human adult heart, lung, lymphoblasts, and placenta as well as fetal lung, liver, and kidney. In embryo, expressed in the outflow tract and atrium of the devel

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

ADA2; ADGF; CECR1; IDGFLAdenosine deaminase 2; EC 3.5.4.4; Cat eye syndrome critical region protein 1

Target Background

This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants.