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The antibody against NASP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 180-449 of human NASP (NP_689511.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against NASP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 180-449 of human NASP (NP_689511.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-02783A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NASP |
| Target Synonyms | HMDRA1; FLB7527; PRO1999; NASP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, HL-60, SW620 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 180-449 of human NASP (NP_689511.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P49321 | Immunogen Sequence |
Uniprot Id
P49321
Target Species
Human
Target Name
NASP
Target Full Name
Nuclear autoantigenic sperm protein
Target Function
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
NASP family
Target Tissue Specificity
Isoform 1 is testis- and sperm-specific.
Target Synonyms
5033430J04Rik; AI131596; AI317140; D4Ertd767e; DKFZp547F162; Epcs32; FLB7527; FLJ31599; FLJ35510; MGC19722; MGC20372; MGC2297; MGC93869; NASP; NASP_HUMAN; nuclear autoantigenic sperm protein (histone binding); Nuclear autoantigenic sperm protein; PRO1999; RP23 233B9.9
Target Background
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.
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