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The antibody against DPYS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 250-519 of human DPYS (NP_001376.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DPYS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 250-519 of human DPYS (NP_001376.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03066A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DPYS |
| Target Synonyms | DHP; DHPase; DPYS | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Mouse liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 250-519 of human DPYS (NP_001376.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q14117 | Immunogen Sequence |
Uniprot Id
Q14117
Target Species
Human
Target Name
DPYS
Target Full Name
Dihydropyrimidinase
Target Function
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
Target Involvement
Dihydropyrimidinase deficiency (DPYSD)
Target Protein Families
Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
Target Tissue Specificity
Liver and kidney.
Target Synonyms
DHP; DHPase; Dihydropyrimidinase; Dihydropyrimidine amidohydrolase; Dpys; DPYS_HUMAN; Hydantoinase
Target Background
Dihydropyrimidinase catalyzes the conversion of 5, 6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
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