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The antibody against RASIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 635-785 of human RASIP1 (Q5U651) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against RASIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 635-785 of human RASIP1 (Q5U651) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-03114A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RASIP1 |
| Target Synonyms | RAIN; RASIP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BxPC-3, Mouse skeletal muscle, Rat skeletal muscle | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 635-785 of human RASIP1 (Q5U651). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | TPEAVSVELRPLMLWMANTTELLSFVQEKVLEMEKEADQEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLN | Uniprot ID | Q5U651 |
Uniprot Id
Q5U651
Target Species
Human
Target Name
RASIP1
Target Full Name
Ras-interacting protein 1
Target Function
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy
Target Subcellular Location
Cytoplasm, perinuclear region. Golgi apparatus, Golgi stack. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.
Target Tissue Specificity
Highly expressed in heart. Detected at lower levels in placenta and pancreas.
Target Synonyms
FLJ20401; Rain; RAIN protein fragment; RAIN_HUMAN; Ras interacting protein 1; Ras-interacting protein 1; RASIP 1; RASIP1; RASIP1 protein
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