Rabbit anti-Human SLC6A18 Polyclonal Antibody

The antibody against SLC6A18 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 310-400 of human SLC6A18 (NP_872438.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03291A

Number

Cat.No	ADA-03291A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SLC6A18
Target Synonyms	Xtrp2; SLC6A18	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse kidney, 293T, Rat kidney	Application	ELISA, WB

Cat.No

ADA-03291A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SLC6A18

Target Synonyms

Xtrp2; SLC6A18

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse kidney, 293T, Rat kidney

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 310-400 of human SLC6A18 (NP_872438.2).	Target Species	Human
Immunogen Sequence	VLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAP	Uniprot ID	Q96N87

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 310-400 of human SLC6A18 (NP_872438.2).

Target Species

Human

Immunogen Sequence

VLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAP

Uniprot ID

Q96N87

Background Information

Uniprot Id

Q96N87
Target Species

Human
Target Name

SLC6A18
Target Full Name

Inactive sodium-dependent neutral amino acid transporter B(0)AT3
Target Function

Does not show neutral amino acid transporter activity.
Target Involvement

Genetic variations in SLC6A18 might contribute to the disease phentotype in some individuals with iminoglycinuria or hyperglycinuria, that carry variants in SLC36A2, SLC6A19 or SLC6A20 (PubMed:19033659).
Target Subcellular Location

Membrane; Multi-pass membrane protein.
Target Protein Families

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A18 subfamily
Target Tissue Specificity

Abundantly expressed in kidney, but not in intestine.
Target Synonyms

SLC6A18; XTRP2; Inactive sodium-dependent neutral amino acid transporter B(0)AT3; Sodium- and chloride-dependent transporter XTRP2; Solute carrier family 6 member 18; System B(0) neutral amino acid transporter AT3
Target Background

The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).

Rabbit anti-Human SLC6A18 Polyclonal Antibody

Specifications

Immunogen Information

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