Rabbit anti-Human F8 Polyclonal Antibody

Uniprot Id

P00451

Target Species

Human

Target Name

F8

Target Full Name

Coagulation factor VIII

Target Function

Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.

Target Involvement

Hemophilia A (HEMA)

Target Subcellular Location

Secreted, extracellular space.

Target Protein Families

Multicopper oxidase family

Target Research Area

Others

Target Synonyms

AHF; Antihemophilic factor; Coagulation factor VIII; coagulation factor VIII; procoagulant component; coagulation factor VIIIc; DXS1253E; F8; F8b; F8c; FA8_HUMAN; factor VIII F8B; Factor VIIIa light chain; FactorVIII; FVIII; Hema; Hemophilia A; Hemophilia; classic; OTTHUMP00000061446; OTTHUMP00000196174; Procoagulant component

Target Background

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.