Rabbit anti-Human SAR1B Polyclonal Antibody

Uniprot Id

Q9Y6B6

Target Species

Human

Target Name

SAR1B

Target Full Name

Small COPII coat GTPase SAR1B

Target Function

GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.

Target Involvement

Chylomicron retention disease (CMRD)

Target Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.

Target Protein Families

Small GTPase superfamily, SAR1 family

Target Tissue Specificity

Expressed in many tissues including small intestine, liver, muscle and brain.

Target Synonyms

ANDD; CMRD; GTBPB; SARA2; SAR1B

Target Background

The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.