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The antibody against AUTS2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 550-770 of human AUTS2 (NP_001120703) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against AUTS2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 550-770 of human AUTS2 (NP_001120703) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-03984A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AUTS2 |
| Target Synonyms | MRD26; FBRSL2; AUTS2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse skeletal muscle, SH-SY5Y | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 550-770 of human AUTS2 (NP_001120703). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8WXX7 | Immunogen Sequence |
Uniprot Id
Q8WXX7
Target Species
Human
Target Name
AUTS2
Target Full Name
Autism susceptibility gene 2 protein
Target Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation. In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1
Target Involvement
Mental retardation, autosomal dominant 26 (MRD26)
Target Subcellular Location
Nucleus. Cytoplasm, cytoskeleton. Cell projection, growth cone.
Target Protein Families
AUTS2 family
Target Tissue Specificity
Strongly expressed in brain, skeletal muscle and kidney. Also expressed in placenta, lung and leukocytes.
Target Synonyms
Autism related protein 1; Autism susceptibility candidate 2; Autism susceptibility gene 2 protein; AUTS2; AUTS2_HUMAN; FBRSL2; KIAA0442; MGC13140
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