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The antibody against PMM2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-246 of human PMM2 (NP_000294.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against PMM2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-246 of human PMM2 (NP_000294.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-04020A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PMM2 |
| Target Synonyms | PMI; CDG1; CDGS; PMI1; CDG1a; PMM 2; PMM2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, NIH/3T3, Rat brain, 293T, A-549, HepG2, Mouse intestine, Mouse liver | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-246 of human PMM2 (NP_000294.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O15305 | Immunogen Sequence |
Uniprot Id
O15305
Target Species
Human
Target Name
PMM2
Target Full Name
Phosphomannomutase 2
Target Function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Target Involvement
Congenital disorder of glycosylation 1A (CDG1A)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Eukaryotic PMM family
Target Research Area
Signal Transduction
Target Synonyms
AI585868; BOS_22465; C86848; CDG 1; CDG1; CDG1a; CDGS; MGC127449; Phosphomannomutase 2; PMM 2; Pmm2; PMM2_HUMAN
Target Background
The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I.
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