Rabbit anti-Human HSPB8/HSP22 Polyclonal Antibody

Uniprot Id

Q9UJY1

Target Species

Human

Target Name

HSPB8

Target Full Name

Heat shock protein beta-8

Target Function

Displays temperature-dependent chaperone activity.

Target Involvement

Neuronopathy, distal hereditary motor, 2A (HMN2A); Charcot-Marie-Tooth disease 2L (CMT2L)

Target Subcellular Location

Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.

Target Protein Families

Small heat shock protein (HSP20) family

Target Tissue Specificity

Predominantly expressed in skeletal muscle and heart.

Target Synonyms

Alpha crystallin C chain; Alpha-crystallin C chain; Charcot Marie Tooth disease axonal type 2L; Charcot Marie Tooth disease spinal; CMT2L; CRYAC; DHMN 2; DHMN2; E2 induced gene 1 protein; E2-induced gene 1 protein; E2IG1; H11; Heat shock 22kDa protein 8; Heat shock 27kDa protein 8; Heat shock protein 22; Heat shock protein beta 8; Heat shock protein beta-8; Hereditary motor neuropathy distal; HMN 2; HMN2; HMN2A; HSB8; HSPB 8; HspB8; HSPB8_HUMAN; OTTHUMP00000239768; Protein kinase H11; Small stress protein like protein HSP22; Small stress protein-like protein HSP22; Spinal muscular atrophy distal adult autosomal dominant

Target Background

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.