Rabbit anti-Human GNAI3 Polyclonal Antibody

Uniprot Id

P08754

Target Species

Human

Target Name

GNAI3

Target Full Name

Guanine nucleotide-binding protein G(i) subunit alpha-3

Target Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. Stimulates the activity of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.

Target Involvement

Auriculocondylar syndrome 1 (ARCND1)

Target Subcellular Location

Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Target Protein Families

G-alpha family, G(i/o/t/z) subfamily

Target Research Area

Cell Cycle

Target Synonyms

87U6; FLJ26559; G protein alpha inhibiting 3; G(i) alpha 3 ; G(i) alpha-3; GNAI3; GNAI3_HUMAN; Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 ; Guanine nucleotide binding protein G(k) alpha subunit; Guanine nucleotide-binding protein G(k) subunit alpha; OTTHUMP00000013368

Target Background

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway.