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The antibody against ARSA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human ARSA (NP_000478.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ARSA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human ARSA (NP_000478.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04521A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ARSA |
| Target Synonyms | ASA; MLD; ARSA | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, A-549, HepG2, Jurkat, Mouse brain, Mouse liver, Mouse testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human ARSA (NP_000478.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P15289 | Immunogen Sequence |
Uniprot Id
P15289
Target Species
Human
Target Name
ARSA
Target Full Name
Arylsulfatase A
Target Function
Hydrolyzes cerebroside sulfate.
Target Involvement
Metachromatic leukodystrophy (MLD); Multiple sulfatase deficiency (MSD)
Target Subcellular Location
Endoplasmic reticulum. Lysosome.
Target Protein Families
Sulfatase family
Target Synonyms
arsA; ARSA_HUMAN; arylsulfatase A; Arylsulfatase A component C; As 2; AS A; As2; ASA; AW212749; C230037L18Rik; Cerebroside-sulfatase; metachromatic leucodystrophy; MGC125207; MLD; OTTHUMP00000196546; OTTHUMP00000196548; TISP73
Target Background
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.
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