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The antibody against HCN1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 791-890 of human HCN1 (NP_066550.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against HCN1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 791-890 of human HCN1 (NP_066550.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-04573A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HCN1 |
| Target Synonyms | BCNG1; DEE24; HAC-2; BCNG-1; EIEE24; GEFSP10; HCN1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Neuro-2a, SH-SY5Y | Application | ELISA, WB, IF/ICC |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 791-890 of human HCN1 (NP_066550.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | PSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL | Uniprot ID | O60741 |
Uniprot Id
O60741
Target Species
Human
Target Name
HCN1
Target Full Name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Target Function
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
Target Involvement
Epileptic encephalopathy, early infantile, 24 (EIEE24)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
Potassium channel HCN family
Target Tissue Specificity
Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.
Target Synonyms
BCNG-1; BCNG1; Brain cyclic nucleotide gated channel 1; Brain cyclic nucleotide-gated channel 1; HAC 2; HAC2; HCN1; HCN1_HUMAN; Hyperpolarization activated cyclic nucleotide gated potassium channel 1; Potassium channel; voltage-gated; brain; 1; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Target Background
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes.
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