Rabbit anti-Human MUTYH Polyclonal Antibody

Uniprot Id

Q9UIF7

Target Species

Human

Target Name

MUTYH

Target Full Name

Adenine DNA glycosylase

Target Function

Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.

Target Involvement

Familial adenomatous polyposis 2 (FAP2); Gastric cancer (GASC)

Target Subcellular Location

Nucleus. Mitochondrion.

Target Protein Families

Nth/MutY family

Target Synonyms

A/G specific adenine DNA glycosylase; A/G-specific adenine DNA glycosylase; Adenine DNA glycosylase ; CYP2C; hMYH; MGC4416; MutY (E. coli) homolog ; MutY homolog (E. coli); MutY homolog; MutY, E. coli, homolog of; Mutyh; MUTYH_HUMAN; MYH; rMYH

Target Background

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7, 8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.