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The antibody against LEFTY1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 77-366 of human LEFTY1 (NP_066277.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against LEFTY1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 77-366 of human LEFTY1 (NP_066277.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05096A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LEFTY1 |
| Target Synonyms | LEFTB; LEFTYB; LEFTY1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BxPC-3, HT-29, Mouse pancreas, Mouse spleen, SW480 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 77-366 of human LEFTY1 (NP_066277.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O75610 | Immunogen Sequence |
Uniprot Id
O75610
Target Species
Human
Target Name
LEFTY1
Target Full Name
Left-right determination factor 1
Target Function
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family
Target Synonyms
LEFTY1; LEFTB; LEFTYB; UNQ278/PRO317Left-right determination factor 1; Left-right determination factor B; Protein lefty-1; Protein lefty-B
Target Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene.
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