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The antibody against ZBTB17 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 121-360 of human ZBTB17 (NP_003434.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ZBTB17 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 121-360 of human ZBTB17 (NP_003434.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05446A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZBTB17 |
| Target Synonyms | MIZ-1; ZNF60; ZNF151; pHZ-67; ZBTB17 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, B-cell | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 121-360 of human ZBTB17 (NP_003434.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13105 | Immunogen Sequence |
Uniprot Id
Q13105
Target Species
Human
Target Name
ZBTB17
Target Full Name
Zinc finger and BTB domain-containing protein 17
Target Function
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1
Target Subcellular Location
Nucleus.
Target Protein Families
Krueppel C2H2-type zinc-finger protein family
Target Tissue Specificity
Expressed in germinal center B-cells.
Target Synonyms
Miz-1; Myc-interacting zinc finger protein 1; Myc-interacting zinc finger protein; ZBT17; ZBT17_HUMAN; Zbtb17; Zinc finger and BTB domain containing protein 17; Zinc finger and BTB domain-containing protein 17; Zinc finger protein 151; Zinc finger protein 60; ZNF151; ZNF60
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