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The antibody against GPD1L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human GPD1L (NP_055956.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GPD1L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human GPD1L (NP_055956.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05670A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GPD1L |
| Target Synonyms | GPD1-L; GPD1L | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, 293T, A-549, Mouse brain, Mouse stomach, Mouse thymus, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human GPD1L (NP_055956.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8N335 | Immunogen Sequence |
Uniprot Id
Q8N335
Target Species
Human
Target Name
GPD1L
Target Full Name
Glycerol-3-phosphate dehydrogenase 1-like protein
Target Function
Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
Target Involvement
Brugada syndrome 2 (BRGDA2); Sudden infant death syndrome (SIDS)
Target Subcellular Location
Cytoplasm. Note=Localized to the region of the plasma membrane.
Target Protein Families
NAD-dependent glycerol-3-phosphate dehydrogenase family
Target Tissue Specificity
Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.
Target Synonyms
GPD1L; KIAA0089; Glycerol-3-phosphate dehydrogenase 1-like protein; GPD1-L; EC 1.1.1.8
Target Background
The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS).
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