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The antibody against BTD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 284-543 of human BTD (NP_000051.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against BTD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 284-543 of human BTD (NP_000051.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05915A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BTD |
| Target Synonyms | BTD | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Jurkat, Mouse liver, Rat kidney | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 284-543 of human BTD (NP_000051.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P43251 | Immunogen Sequence |
Uniprot Id
P43251
Target Species
Human
Target Name
BTD
Target Full Name
Biotinidase
Target Function
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
Target Involvement
Biotinidase deficiency (BTD deficiency)
Target Subcellular Location
Secreted, extracellular space.
Target Protein Families
Carbon-nitrogen hydrolase superfamily, BTD/VNN family
Target Research Area
Metabolism
Target Synonyms
Biotinase; Biotinidase; Btd; BTD_HUMAN; EC 3.5.1.12
Target Background
The protein encoded by this gene functions to recycle protein-bound biotin by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. The encoded protein has also been shown to have biotinyl transferase activity. Mutations in this gene are associated with biotinidase deficiency. Multiple transcript variants encoding different isoforms have been described.
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