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The antibody against AXIN2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 9-600 of human AXIN2 (NP_004646.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against AXIN2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 9-600 of human AXIN2 (NP_004646.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06282A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AXIN2 |
| Target Synonyms | AXIL; ODCRCS; AXIN2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, HCT116, HepG2, Mouse brain, mouse fetal, SW620 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 9-600 of human AXIN2 (NP_004646.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y2T1 | Immunogen Sequence |
Uniprot Id
Q9Y2T1
Target Species
Human
Target Name
AXIN2
Target Full Name
Axin-2
Target Function
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Target Involvement
Colorectal cancer (CRC); Oligodontia-colorectal cancer syndrome (ODCRCS)
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Expressed in brain and lymphoblast.
Target Research Area
Cancer
Target Synonyms
Axil; Axin like protein; Axin-2; Axin-like protein; Axin2; AXIN2_HUMAN; Axis inhibition protein 2; Conductin; DKFZp781B0869; MGC10366; MGC126582
Target Background
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
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