Rabbit anti-Human VASH1 Polyclonal Antibody

The antibody against VASH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human VASH1 (NP_055724.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-06325A

Number

Cat.No	ADA-06325A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	VASH1
Target Synonyms	TTCP 1; KIAA1036; VASH1	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse brain, Mouse stomach	Application	ELISA, WB

Cat.No

ADA-06325A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

VASH1

Target Synonyms

TTCP 1; KIAA1036; VASH1

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse brain, Mouse stomach

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human VASH1 (NP_055724.1).	Target Species	Human
Uniprot ID	Q7L8A9	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human VASH1 (NP_055724.1).

Target Species

Human

Uniprot ID

Q7L8A9

Immunogen Sequence

Background Information

Uniprot Id

Q7L8A9
Target Species

Human
Target Name

VASH1
Target Full Name

Tubulinyl-Tyr carboxypeptidase 1
Target Function

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts.
Target Subcellular Location

Cytoplasm. Secreted.
Target Protein Families

Vasohibin family
Target Tissue Specificity

Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.
Target Research Area

Cardiovascular
Target Synonyms

KIAA1036; VASH; VASH1; VASH1_HUMAN; Vasohibin 1; Vasohibin-1
Target Background

Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; and negative regulation of lymphangiogenesis. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis.

Rabbit anti-Human VASH1 Polyclonal Antibody

Specifications

Immunogen Information

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