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The antibody against PUS7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 352-661 of human PUS7 (NP_061915.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PUS7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 352-661 of human PUS7 (NP_061915.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07037A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PUS7 |
| Target Synonyms | IDDABS; PUS7 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse brain, Mouse liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 352-661 of human PUS7 (NP_061915.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96PZ0 | Immunogen Sequence |
Uniprot Id
Q96PZ0
Target Species
Human
Target Name
PUS7
Target Full Name
Pseudouridylate synthase 7 homolog
Target Function
Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types.
Target Subcellular Location
Nucleus.
Target Protein Families
Pseudouridine synthase TruD family
Target Synonyms
FLJ20485; KIAA1897; MGC17720; OTTHUMP00000212074; OTTHUMP00000212075; OTTHUMP00000212076; Pseudouridylate synthase 7 (putative); Pseudouridylate synthase 7 homolog (S. cerevisiae); Pseudouridylate synthase 7 homolog; PUS7; PUS7_HUMAN
Target Background
Enables enzyme binding activity and pseudouridine synthase activity. Involved in several processes, including pseudouridine synthesis; regulation of hematopoietic stem cell differentiation; and regulation of mesoderm development. Located in nucleus.
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