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The antibody against SCIN was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human SCIN (NP_001106177.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against SCIN was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human SCIN (NP_001106177.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-07106A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SCIN |
| Target Synonyms | SCIN; adseverin | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HT-29, SGC-7901 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SCIN (NP_001106177.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MARELYHEEFARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQ | Uniprot ID | Q9Y6U3 |
Uniprot Id
Q9Y6U3
Target Species
Human
Target Name
SCIN
Target Full Name
Scinderin
Target Function
Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, podosome.
Target Protein Families
Villin/gelsolin family
Target Tissue Specificity
Expressed in megakaryocytes.
Target Research Area
Signal Transduction
Target Synonyms
Adseverin; ADSV_HUMAN; KIAA1905; Scin; Scinderin
Target Background
SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).
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