Rabbit anti- YKL-40/CHI3L1 Polyclonal Antibody

Uniprot Id

P36222

Target Species

Human

Target Name

CHI3L1

Target Full Name

Chitinase-3-like protein 1

Target Function

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung

Target Involvement

Asthma-related traits 7 (ASRT7); Schizophrenia (SCZD)

Target Subcellular Location

Secreted, extracellular space. Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.

Target Protein Families

Glycosyl hydrolase 18 family

Target Tissue Specificity

Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.

Target Research Area

Signal Transduction

Target Synonyms

39 kDa synovial protein; ASRT7; Cartilage glycoprotein 39; CGP-39; CGP39; CH3L1_HUMAN; CHI3L1; chitinase 3 like 1 (cartilage glycoprotein 39) ; chitinase 3 like 1; Chitinase 3 like protein 1 precursor ; chitinase; Chitinase-3-like protein 1; Chondrocyte protein YKL40; GP 39; GP-39; GP39; HC gp39 ; HCGP 3P ; hCGP-39; HCgp39; YKL 40; YKL-40; YKL40; YYL 40