Rabbit anti-Human MCOLN2 Polyclonal Antibody

The antibody against MCOLN2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 90-275 of human MCOLN2 (NP_694991.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-07322A

Number

Cat.No	ADA-07322A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	MCOLN2
Target Synonyms	TRPML2; TRP-ML2; MCOLN2	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	SKOV3, THP-1	Application	ELISA, WB

Cat.No

ADA-07322A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

MCOLN2

Target Synonyms

TRPML2; TRP-ML2; MCOLN2

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

SKOV3, THP-1

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 90-275 of human MCOLN2 (NP_694991.2).	Target Species	Human
Immunogen Sequence	VVAFKEDNTVAFKHLFLKGYSGTDEDDYSCSVYTQEDAYESIFFAINQYHQLKDITLGTLGYGENEDNRIGLKVCKQHYKKGTMFPSNETLNIDNDVELDCVQLDLQDLSKKPPDWKNSSFFRLEFYRLLQVEISFHLKGIDLQTIHSRELPDCYVFQNTIIFDNKAHSGKIKIYFDSDAKIEECK	Uniprot ID	Q8IZK6

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 90-275 of human MCOLN2 (NP_694991.2).

Target Species

Human

Immunogen Sequence

VVAFKEDNTVAFKHLFLKGYSGTDEDDYSCSVYTQEDAYESIFFAINQYHQLKDITLGTLGYGENEDNRIGLKVCKQHYKKGTMFPSNETLNIDNDVELDCVQLDLQDLSKKPPDWKNSSFFRLEFYRLLQVEISFHLKGIDLQTIHSRELPDCYVFQNTIIFDNKAHSGKIKIYFDSDAKIEECK

Uniprot ID

Q8IZK6

Background Information

Uniprot Id

Q8IZK6
Target Species

Human
Target Name

MCOLN2
Target Full Name

Mucolipin-2
Target Function

Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
Target Protein Families

Transient receptor (TC 1.A.4) family, Polycystin subfamily, MCOLN2 sub-subfamily
Target Synonyms

MCOLN2; Mucolipin-2; Transient receptor potential channel mucolipin 2; TRPML2

Rabbit anti-Human MCOLN2 Polyclonal Antibody

Specifications

Immunogen Information

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