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Rabbit anti-Human SLC22A3/OCT3 Polyclonal Antibody

The antibody against SLC22A3/OCT3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 289-349 of human SLC22A3/OCT3 (NP_068812.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-07334A

The antibody against SLC22A3/OCT3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 289-349 of human SLC22A3/OCT3 (NP_068812.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-07334A ClonalityPolyclonal
Host SpeciesRabbitTarget NameSLC22A3/OCT3
Target SynonymsEMT; EMTH; OCT3; SLC22A3/OCT3FormLiquid
Species ReactivityMouseIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.01% thimerosal, pH7.3.Purification MethodAffinity purification
Positive SamplesMouse liverApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 289-349 of human SLC22A3/OCT3 (NP_068812.1).Target SpeciesHuman
Immunogen SequencePESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKUniprot IDO75751
Background Information
  • Uniprot Id

    O75751

  • Target Species

    Human

  • Target Name

    SLC22A3

  • Target Full Name

    Solute carrier family 22 member 3

  • Target Function

    Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

  • Target Subcellular Location

    Membrane; Multi-pass membrane protein.

  • Target Protein Families

    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family

  • Target Tissue Specificity

    Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.

  • Target Synonyms

    SLC22A3; EMTH; OCT3; Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3

  • Target Background

    Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.

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